My microwave hates me

[susandennis]

I wanted a single poached egg with my coffee between volleyball and elbow coffee. So, as usual, I put the egg into the water and the glass into the microwave and hit 60 seconds. I sent back the splatter covers I've been using but I'm still used to their being there for protection. There were not. At 51 seconds - boom!! A little water was in the glass but the egg was splattered all over the door and the inside of the microwave. I opened the door and egg drooled down onto the stove. What a gynormous mess.

I had toast.

I'm not looking forward to elbow coffee. My spidey senses tell me some of Myrna's hateful family will be there. I'm very tempted to pull a Martha and skip it this week but I feel like I need a good reason and I don't have one. Plus I don't want to be bullied out of my group by those assholes. So. I will go. Lock my lip zipper and play with my phone if I have to.

I got new a new allergy drug yesterday - fexofenadine. So far so good at fixing the problem and does not make me sleepy. But doing my due Google diligence, I found an issue with a drug I use. All it said was minor contraindication with ketoconazole. I use ketoconazole in cream form - bit about the size of a rice grain on two spots on my face maybe every other day or so.

Curiosity led me to this delicious paragraph. I love the wording and the words and that it took all of them together to say No Big Deal.

Coadministration with ketoconazole has been shown to significantly increase the oral bioavailability of fexofenadine. The proposed mechanism is ketoconazole inhibition of the intestinal efflux of fexofenadine via P-glycoprotein transporter. In 24 healthy volunteers, coadministration of fexofenadine 120 mg twice a day and ketoconazole 400 mg once a day resulted in a 135% and 164% increase in the steady-state fexofenadine peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of fexofenadine alone. However, no increase in adverse effects or QTc interval were noted. No studies have been performed using other azole antifungal agents, but similar results are possible given their similarities to ketoconazole. Fexofenadine had no effect on the pharmacokinetics of ketoconazole.

Kudos to the author.

No big plans - just hoping for a inoffensive coffee and a lovely afternoon with me and the TV and the knitting needles.

Comments

[seasonedrite]

I think you took my typical egg boom! because mine did not boom today. I covered it with my silicone pot lid (as usual) and was pleasantly surprised at the silent cooking. I started nuking poached eggs after you originally told us about it and I've been so happy with it. The first time I tried making one I forgot to cover it, and then kicked myself so hard for not remembering four very simple steps: water in bowl, crack egg into bowl, cover and nuke.

Today's egg went into a small chopped salad for breakfast (iceberg lettuce, grape tomatoes, cauliflower, orange peppers, pepitas, celery and ranch dressing). I have a commercial grade microwave and the yolk was 80% cooked, 20% soft which worked out just fine for the salad.

[susandennis]

Oh crap! I have a silicone lid that I totally forgot about!

Thanks... It takes a village

[historicalmuse]

Sorry about your eggs. :/ Things like that happen non??

[mtbc]

Fexofenadine and ketoconazole have both worked excellently for me, though now I realize I don't think I've ever needed them simultaneously, at least it doesn't sound like it much matters either way.